Peptide epitope generation for MHC class I presentation is normally dependent upon proteasome activity. Yet this pathway fails to generate critical HIV epitopes. Instead, the protease TPPII is required for this activity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Seifert, U. et al. Nat. Immunol. 4, 375–379 (2003).
Roelse, J., Gromme, M., Momburg, F., Hammerling, G. & Neefjes, J. J. Exp. Med. 180, 1591–1597 (1994).
Saric, T. et al. J. Biol. Chem. 276, 36474–36481 (2001).
Reits, E. et al. Immunity 18, 97–108 (2003).
Neisig, A. et al. J. Immunol. 154, 1273–1279 (1995).
Serwold, T., Gonzalez, F., Kim, J., Jacob, R. & Shastri, N. Nature 419, 480–483 (2002).
York, I.A. et al. Nat. Immunol. 3, 1177–1184 (2002).
Saric, T. et al. Nat. Immunol. 3, 1169–1176 (2002).
Cascio, P., Hilton, C., Kisselev, A.F., Rock, K.L. & Goldberg, A.L. EMBO J. 20, 2357–2366 (2001).
Benham, A.M., Gromme, M. & Neefjes, J. J. Immunol. 161, 83–89 (1998).
Geier, E. et al. Science 283, 978–981 (1999).
Tomkinson, B. Trends Biochem. Sci. 24, 355–359 (1999).
Lam, Y.A., Lawson, T.G., Velayutham, M., Zweier, J.L. & Pickart, C.M. Nature 416, 763–767 (2002).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Herberts, C., Reits, E. & Neefjes, J. Proteases, proteases and proteases for presentation. Nat Immunol 4, 306–308 (2003). https://doi.org/10.1038/ni0403-306
Issue Date:
DOI: https://doi.org/10.1038/ni0403-306