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Policing the regulators

Nature Immunology volume 2, pages 283–284 (2001)Cite this article

Abstract

Prevention of autoimmunity apparently cannot be achieved by negative selection and peripheral anergy or deletion alone. Regulatory T cells are selected in the thymus to control autoreactive thymic escapees.

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Figure 1: Immunological self-tolerance maintained by CD25+CD4+ regulatory T cells and their production by the thymus.

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Authors and Affiliations

  1. Department of Experimental Pathology, Institute for Frontier Medical Sciences Kyoto University, Kyoto, 606-8507, Japan

    Shimon Sakaguchi

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  1. Shimon Sakaguchi
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Sakaguchi, S. Policing the regulators. Nat Immunol 2, 283–284 (2001). https://doi.org/10.1038/86283

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