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Autoimmunity versus horror autotoxicus: The struggle for recognition

Historical insight: Paul Ehrlich's dictum of horror autotoxicus and the changing orientation of the field inhibited acceptance of the reality of autoimmune disease.

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References

  1. Rose, N. R. & Mackay, I. R. (eds) The Autoimmune Diseases p. iv (New York, Academic Press, 1985).

    Google Scholar 

  2. Silverstein, A. M. Nature Immunol. 1, 93–94 (2000).

    CAS  Article  Google Scholar 

  3. Silverstein, A. M. Nature Immunol. 1, 453–455 (2000).

    CAS  Article  Google Scholar 

  4. The Donath-Landsteiner finding raised a number of interesting epistemological and semantic questions that are discussed in detail in Silverstein, A. M. Cell. Immunol. 97, 173–188 (1898).

  5. Fleck, L. Genesis and Development of a Scientific Fact (University of Chicago Press, Chicago, 1979).

    Google Scholar 

  6. Bordet, J. Ann. Inst. Pasteur 12, 688–695 (1898).

    Google Scholar 

  7. Ehrlich, P. & Morgenroth, J. Berlin klin. Wochenschr. 36, 6–9 & 481–486 (1899); 37, 453–458 & 681–687 (1900); 38, 251–257 & 569–574 (1901). (Translations: Ehrlich, P. in The Collected Papers of Paul Ehrlich Vol. II, Pergamon, New York, 1957.)

    Google Scholar 

  8. Ehrlich, P. 73 Verh. Ges. Dtsch. Naturforsch. Aerzte 1, 250–275 (1902). (Translations: Ehrlich, P. in Collected Studies on Immunity, p. 388, Wiley, New York, 1906.)

    Google Scholar 

  9. Metalnikoff, S. Ann. Inst. Pasteur 14, 577–589 (1900).

    CAS  Google Scholar 

  10. Ehrlich, P. & Morgenroth, J. Berlin klin. Wochenschr. 38, 251 & 255 (1901).

    Google Scholar 

  11. For an excellent exposition of the meaning of horror autotoxicus, see the monograph by Dietlinde Goltz, Horror Autotoxicus: Ein Beitrag zur Geschichte und Theorie der Autoimmunpathologie im Spiegel eines vielzitierten Begriffes (Thesis, Univerity of Münster, 1980).

  12. Donath, J. Z. klin. Med. 52, 1–39 (1904).

    Google Scholar 

  13. Landsteiner, K. Centralbl. Bakteriol. Orig. 27, 357–360 (1900); Wien. klin. Wochenschr. 14, 1132–1134 (1901). Landsteiner would later discover the M, N and P erythrocyte antigen system with Philip Levine [Proc. Soc. Soc. Exp. Biol. Med. 24, 600–602 & 941–942 (1926)] and the Rh antigen system with Alexander Wiener [Proc. Soc. Soc. Exp. Biol. Med. 43, 223–224 (1940)].

    Google Scholar 

  14. Donath, J. & Landsteiner, K. Münch. med. Wochenschr. 51, 1590–1593 (1904).

    Google Scholar 

  15. For example, Donath J. & Landsteiner, K., Z. klin. Med. 58, 173–189 (1906); Zentralbl. Bakteriol. Parasitenk. 45, 205–213 (1908); Zentralbl. Immunitätsforsch. 18, 701–704 (1913); Landsteiner, K. Handbuch der Biochemie, Vol. 1, 492–494 (Jena, Fischer, 1910).

    Google Scholar 

  16. Ehrlich, Collected Studies, note 8, p. 581.

  17. Erq. Allq. Pathol. 11, 515–644 (1907), p. 565.

  18. Rose, N. R. Personal communication (1986).

  19. Elschnig, A. Albrecht von Graefes Arch. Ophthalmol. 76,509–546 (1910); Collins, R. C. Am J. Ophthalmol. 36, 150–162 (1953).

    Article  Google Scholar 

  20. Krusius, F.F. Arch. Augenheilk. 67, 6–35 (1910); Römer, P. & Gebb, H., Albrecht von Graefes Arch. Ophthalmol. 81, 367–402 (1912).

    Google Scholar 

  21. Chauffard, A. & Troisier, J. Sem. Medicale (Paris) 25, 411–420 (1908); Dameshek, W. & Schwartz, S. O. N. Engl. J. Med. 218, 15–38 (1938). Coombs, R. R. A., Mourant, A. E. & Race, R. R. Brit. J. Exp. Pathol. 26, 255–266 (1945); Dacie, J. V. The Haemolytic Anemias 2nd edn (Grune & Stratton, New York, 1962).

    Google Scholar 

  22. Rivers, T. M., Schwentker, E. F. & Berry, G. P. J. Exp. Med. 58, 39–53 (1933); Rivers, T. M. & Schwentker, E. F. J. Exp. Med. 61, 689–702 (1935); Kabat, E. A., Wolf, A. & Bezer, A. E. J. Exp. Med. 85, 117–130 (1947) & 89, 395–398 (1949).

    CAS  Article  Google Scholar 

  23. Ackroyd, J. F. Clin. Sci. 8, 269–287 (1949).

    CAS  PubMed  Google Scholar 

  24. Voisin, G. Delaunay, A. & Barber, M. Ann. Inst. Pasteur 81, 48–63 (1951).

    CAS  Google Scholar 

  25. Witebsky, E. Ann. NY Acad. Sci. 59, 168–181 (1954), p. 173.

    CAS  Article  Google Scholar 

  26. Witebsky, E. & Rose, N. R. J. Immunol. 76, 408–414 (1956); Rose, N. R. & Witebsky, E. J. Immunol. 76, 417–427 (1956). Almost simultaneously, Roitt et al. published similar findings in human Hashimoto's disease [Lancet 2, 820–822 (1956)].

    CAS  PubMed  Google Scholar 

  27. I have expanded elsewhere on the conceptual changes that occurred during immunology's first century in Silverstein, A. M. Cell. Immunol. 132, 515–531 (1991).

    CAS  Article  Google Scholar 

  28. Landsteiner, K. The Specificity of Serological Reactions, revised edn (Dover, New York, 1962).

    Google Scholar 

  29. For example, Kabat E. E. & Mayer, M. M. Experimental Immunochemistry (Chas. C. Thomas, Springfield IL, 1948).

    Google Scholar 

  30. Boyd, W. C. Fundamentals of Immunology 3rd edn (Interscience, New York, 1956).

    Google Scholar 

  31. For example, Pressman, D. & Grossberg, A. The Structural Basis of Antibody Specificity (Benjamin, New York, 1968); Kabat, E. A. Structural Concepts in Immunology and Immunochemistry (Holt, Rinehart, & Winston, New York, 1968).

    Google Scholar 

  32. For example, Wells, H. G. The Chemical Aspects of Immunity (Chemical Catalog Co., New York, 1924) and Marrack, J. R. The Chemistry of Antigens and Antibodies (HR Stationery Office, London, 1934). Only in 1963 would texts appear aimed primarily at biologists and physicians, Humphrey, J. H. & White, R. G. Immunology for Students of Medicine (Davis, Philadelphia, 1963) and Gell, P. G. H. & Coombs, R. R. A. Clinical Aspects of Immunology (Blackwell, Oxford, 1963).

    Google Scholar 

  33. These were the instruction theories of antibody formation, which held that the antigen controlled the organization of the specific site on the antibody molecule. See Breinl, F. & Haurowitz, F. Z. Physiol. Chem. 192, 45–57 (1930); Pauling, L. J. Am. Chem. Soc. 62, 2643–2657 (1940).

    CAS  Article  Google Scholar 

  34. Zinsser, H. J. Exp. Med. 34, 495–524 (1921); Zinsser, H. & Mueller, J. H. J. Exp. Med. 41, 159–177 (1925); Rich, A. R. & Lewis, M. R. Bull. Johns Hopkins Hosp. 50, 115–131 (1932).

    CAS  Article  Google Scholar 

  35. Dienes, L. & Schoenheit, D. W. Am. Rev. Tuberc. 20, 92–105 (1929); Simon, F. A. & Rackemann, F. M. J. Allergy 5, 439–450 & 451–454 (1934).

    CAS  Google Scholar 

  36. Medawar, P. B. Harvey Lect. 52, 144–176 (1956–1957).

    Google Scholar 

  37. The concept of immunological tolerance was implicit in Ray Owen's report on chimerism [ Owen, R. D. Science 102, 400–401 (1945)], made explicit in F. M. Burnet & F. Fenner's The Production of Antibodies 2nd edn (Macmillan, New York, 1949), and proved experimentally by R. E. Billingham, L. Brent, & P. B. Medawar [Nature 172, 603–606 (1953)]. The demonstration earned for Burnet and Medawar the Nobel Prize in Physiology or Medicine for 1960.

    Google Scholar 

  38. For example, Bergsma, D. & Good, R. A. (eds) Immunological Deficiency Diseases in Man (National Foundation, New York, 1968).

    Google Scholar 

  39. Burnet, F. M. The Clonal Selection Theory of Antibody Formation (Cambridge University Press, London, 1959).

    Google Scholar 

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Silverstein, A. Autoimmunity versus horror autotoxicus: The struggle for recognition. Nat Immunol 2, 279–281 (2001). https://doi.org/10.1038/86280

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