Mitochondrial control of the NLRP3 inflammasome

During the past few decades, the vital and lethal functions of mitochondria have been investigated extensively. Data now demonstrate that these organelles also regulate the innate immune response by modulating inflammasome-mediated generation of proinflammatory cytokines.

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Figure 1: Mitochondrial death and danger signaling.

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Correspondence to Guido Kroemer.

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Kepp, O., Galluzzi, L. & Kroemer, G. Mitochondrial control of the NLRP3 inflammasome. Nat Immunol 12, 199–200 (2011). https://doi.org/10.1038/ni0311-199

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