Direct evaluation of the contribution of somatic hypermutation (SHM) to mucosal immunity has been hampered by the lack of models able to dissociate SHM from class-switch recombination, which are both dependent on the cytidine deaminase AID. A new mouse AID model now demonstrates the critical role of SHM in the control of gut bacteria.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Honjo, T., Kinoshita, K. & Muramatsu, M. Annu. Rev. Immunol. 20, 165–196 (2002).
Muramatsu, M. et al. Cell 102, 553–563 (2000).
Wei, M. et al. Nat. Immunol. 12, 264–270 (2011).
Macpherson, A.J. & Harris, N.L. Nat. Rev. Immunol. 4, 478–485 (2004).
Sansonetti, P.J. Nat. Rev. Immunol. 4, 953–964 (2004).
Cerutti, A. & Rescigno, M. Immunity 28, 740–750 (2008).
Fagarasan, S. et al. Science 298, 1424–1427 (2002).
Suzuki, K. et al. Proc. Natl. Acad. Sci. USA 101, 1981–1986 (2004).
Shinkura, R. et al. Nat. Immunol. 5, 707–712 (2004).
Hapfelmeier, S. et al. Science 328, 1705–1709 (2010).
Snel, J. et al. Int. J. Syst. Bacteriol. 45, 780–782 (1995).
Gaboriau-Routhiau, V. et al. Immunity 31, 677–689 (2009).
Flajnik, M.F. Nat. Rev. Immunol. 2, 688–698 (2002).
Liu, Y.J. et al. Immunity 4, 603–613 (1996).
Chen, K. et al. Nat. Immunol. 10, 889–898 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Chen, K., Cerutti, A. AIDing the pursuit of IgA diversity. Nat Immunol 12, 197–198 (2011). https://doi.org/10.1038/ni0311-197
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni0311-197
