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Controlling stem cell fate one substrate at a time

Hematopoietic stem cell self-renewal is tightly regulated. Regulation of the stability of c-Myc protein contributes to this control of hematopoietic stem cell quiescence and repopulation.

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Figure 1: Regulatory mechanisms that mediate the HSC state.

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Correspondence to Derrick J Rossi.

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Garrison, B., Rossi, D. Controlling stem cell fate one substrate at a time. Nat Immunol 11, 193–194 (2010). https://doi.org/10.1038/ni0310-193

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