Finally, MALT1 is a protease!

Two groups demonstrate proteolytic activity for MALT1, a component of the signaling pathway mediating antigen receptor–dependent stimulation of the transcription factor NF-κB, and identify its first substrates.

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Figure 1: The MALT1 caspase-like domain has proteolytic activity.

Katie Ris-Vicari

References

  1. 1

    Isaacson, P.G. & Du, M.Q. Nat. Rev. Cancer 4, 644–653 (2004).

  2. 2

    Uren, A.G. et al. Mol. Cell 6, 961–967 (2000).

  3. 3

    Lucas, P.C. et al. J. Biol. Chem. 276, 19012–19019 (2001).

  4. 4

    Coornaert, B. Nat. Immunol. 9, 263–271 (2008).

  5. 5

    Rebeaud F. Nat. Immunol. 9, 272–281 (2008).

  6. 6

    Schulze-Luehrmann, J. & Ghosh, S. Immunity 25, 701–715 (2006).

  7. 7

    Lucas, P.C. et al. Oncogene 26, 5643–5654 (2007).

  8. 8

    Zhou, H., Du, M.Q. & Dixit, V.M. Cancer Cell 7, 425–431 (2005).

  9. 9

    Sun, L., Deng, L., Ea, C.K., Xia, Z.P. & Chen, Z.J. Mol. Cell 14, 289–301 (2004).

  10. 10

    Zhou, H. et al. Nature 427, 167–171 (2004).

  11. 11

    Heyninck, K. & Beyaert, R. Trends Biochem. Sci. 30, 1–4 (2005).

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McAllister-Lucas, L., Lucas, P. Finally, MALT1 is a protease!. Nat Immunol 9, 231–233 (2008). https://doi.org/10.1038/ni0308-231

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