How T cells 'find' the right dendritic cell

Naive T cells can spend hours 'sampling' dendritic cells before making a stable conjugate with a single dendritic cell. It is the antigen 'dose' that determines how long this process takes.

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Figure 1: A period of T cell motility precedes a period of stable interactions with DCs.

Katie Ris-Vicari

References

  1. 1

    Henrickson, S.E. et al. Nat. Immunol. 9, 282–291 (2008).

  2. 2

    von Andrian, U.H. & Mempel, T.R. Nat. Rev. Immunol. 3, 867–878 (2003).

  3. 3

    Dustin, M.L., Bromley, S.K., Kan, Z., Peterson, D.A. & Unanue, E.R. Proc. Natl. Acad. Sci. USA 94, 3909–3913 (1997).

  4. 4

    Mempel, T.R., Henrickson, S.E. & Von Andrian, U.H. Nature 427, 154–159 (2004).

  5. 5

    Miller, M.J., Safrina, O., Parker, I. & Cahalan, M.D. J. Exp. Med. 200, 847–856 (2004).

  6. 6

    Miller, M.J., Wei, S.H., Parker, I. & Cahalan, M.D. Science 296, 1869–1873 (2002).

  7. 7

    Bousso, P. & Robey, E. Nat. Immunol. 4, 579–585 (2003).

  8. 8

    Hugues, S. et al. Nat. Immunol. 8, 921–930 (2007).

  9. 9

    Shakhar, G. et al. Nat. Immunol. 6, 707–714 (2005).

  10. 10

    Chakraborty, A.K., Dustin, M.L. & Shaw, A.S. Nat. Immunol. 4, 933–936 (2003).

  11. 11

    Huppa, J.B., Gleimer, M., Sumen, C. & Davis, M.M. Nat. Immunol. 4, 749–755 (2003).

  12. 12

    Iezzi, G., Karjalainen, K. & Lanzavecchia, A. Immunity 8, 89–95 (1998).

  13. 13

    Yokosuka, T. et al. Nat. Immunol. 6, 1253–1262 (2005).

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Shaw, A. How T cells 'find' the right dendritic cell. Nat Immunol 9, 229–230 (2008). https://doi.org/10.1038/ni0308-229

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