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Act1-ivating IL-17 inflammation

The signaling adaptor Act1 is now shown in vivo to be essential for interleukin 17–mediated inflammation in the brain during experimental autoimmune encephalomyelitis and in gut epithelial cells during induced colitis.

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Figure 1: IL-17R signaling requires Act1.

Katie Ris


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Hunter, C. Act1-ivating IL-17 inflammation. Nat Immunol 8, 232–234 (2007).

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