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PD-1 blockade: rescue from a near-death experience

It is unclear whether T cell exhaustion is reversible. A recent Nature paper shows that in vivo blockade of the inhibitory molecule PD-1 can restore the function of exhausted CD8+ T cells during chronic viral infection.

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Figure 1: Mechanisms by which T cell numbers might be enhanced and functional responsiveness might be increased after PD-1 blockade.