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Il2 transcription unleashed by active DNA demethylation

Nature Immunology volume 4, pages 208–209 (2003)Cite this article

The idea that genes are transcriptionally activated by rapid CpG demethylation has been controversial. New data provides the most compelling evidence yet, implicating a mysterious enzyme activity that can actively demethylate DNA.

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Figure 1: Expression of Il2 in activated T cells requires the specific loss of CpG methylation from the proximal promoter region.

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  1. Wellcome Trust Centre for Cell Biology, Kings Buildings, Edinburgh University, Edinburgh, EH9 3JR, UK

    Adrian Bird

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Bird, A. Il2 transcription unleashed by active DNA demethylation. Nat Immunol 4, 208–209 (2003). https://doi.org/10.1038/ni0303-208

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