Multifaceted roles of MHC class I and MHC class I–like molecules in T cell activation

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In addition to the TCR and classical MHC class I, MHC class 1–like molecules can interact with a variety of receptors that play a role in T cell activation. Engagement of NKG2D on CMV-specific αβ CD8+ cells by MIC was found to provide them with a costimulatory signal and augment their cytotoxic response.

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Figure 1: Positive and negative T cell regulation by MHC class I and MHC class I–like molecules.

Bob Crimi

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