A minimal half-life of the TCR-pMHC interaction is required for complete T cell signaling (the kinetic proof reading model). In an extension to this model it is clear that the dwell time or half-life of TCR-pMHC interaction is also critical for T cell activation
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Malissen, B. Les liaisons dangereuses. Nat Immunol 2, 196–198 (2001). https://doi.org/10.1038/85243
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DOI: https://doi.org/10.1038/85243
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