Mal-function of TLRs by SOCS

Suppressor of cytokine signaling 1 has been linked to the negative regulation of Toll-like receptor signaling. The mechanism for this seems to be suppressor of cytokine signaling 1–mediated degradation of the adaptor Mal, which is required for Toll-like receptor signaling.

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Figure 1: The function of SOCS-1 in inhibition of TLR4 signaling and of Mal in mediating p65 Ser 536 phosphorylation of NF-κB.

Katie Ris

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Kobayashi, T., Takaesu, G. & Yoshimura, A. Mal-function of TLRs by SOCS. Nat Immunol 7, 123–124 (2006). https://doi.org/10.1038/ni0206-123

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