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Creating new peptide antigens by slicing and splicing proteins

The proteome universe may be best represented by the peptides caught by major histocompatibility complex proteins. Unusual peptides, such as the post-translationally spliced example seen by the authors of a recent Nature paper, would not be included in a protein world gleaned only from genomics.

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Figure 1: Post-translational modifications of proteins that determine the structure of class I associated peptides.

K.R.

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Engelhard, V. Creating new peptide antigens by slicing and splicing proteins. Nat Immunol 5, 128–129 (2004). https://doi.org/10.1038/ni0204-128

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