News & Views | Published:

Granzyme A: the road less traveled

Cellular parasites have evolved clever anti-apoptosis strategies to avoid being killed by CTLs. However, CTL release of granzyme A inactivates a key repair enzyme, Ape1, ensuring death of infected cells.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Fan, Z. et al. Nat. Immunol. 4, 145–153 (2003).

  2. 2

    Barry, M. & Bleackley, R.C. Nat. Rev. Immunol. 2, 401–409 (2002).

  3. 3

    Trapani, J.A. & Smyth, M.J. Nat. Rev. Immunol. 2, 735–747 (2002).

  4. 4

    Fan, Z., Beresford, P.J., Zhang, D. & Lieberman, J. Mol. Cell. Biol. 22, 2810–2820 (2002).

  5. 5

    Xanthoudakis, S., Miao, G.G. & Curran, T. Proc. Natl. Acad. Sci. USA 91, 23–27 (1994).

  6. 6

    Beresford, P.J., Xia, Z., Greenberg, A.H. & Lieberman, J. Immunity 10, 585–594 (1999).

  7. 7

    Shresta, S., Graubert, T.A., Thomas, D.A., Raptis, S.Z. & Ley, T.J. Immunity 10, 595–605 (1999).

  8. 8

    Szabo, C. & Dawson, V.L. Trends Pharmacol. Sci. 19, 287–298 (1998).

  9. 9

    Leist, M., Single, B., Castoldi, A.F., Kuhnle, S. & Nicotera, P. J. Exp. Med. 185, 1481–1486 (1997).

  10. 10

    D'Amours, D., Sallmann, F.R., Dixit, V.M. & Poirier, G.G. J. Cell. Sci. 114, 3771–3778 (2001).

  11. 11

    Ferguson, T.A. et al. J. Immunol. 168, 5589–5595 (2002).

  12. 12

    Scaffidi, P., Misteli, T. & Bianchi, M.E. Nature 418, 191–195 (2002).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Figure 1: Cytotoxic granule-mediated “roads to ruin.”

Debbie Maizels