The proliferation and differentiation of hematopoietic stem cells is regulated by BMP-4 and Shh. These factors collaborate with cytokines in the bone marrow to create an environment that maintains stem cell homeostasis
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Zon, L. Self-renewal versus differentiation, a job for the mighty morphogens. Nat Immunol 2, 142–143 (2001). https://doi.org/10.1038/84239
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DOI: https://doi.org/10.1038/84239
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