Three recent papers in Nature describe ICOS-deficient mice. ICOS is necessary for normal antibody responses and may be protective against autoimmunity.
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Linsley, P. T cell activation: you can't get good help. Nat Immunol 2, 139–140 (2001). https://doi.org/10.1038/84233
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DOI: https://doi.org/10.1038/84233
