Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Diet, gut microbiota and immune responses

The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a diet-microbiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Diet, microbial composition and regulation of the immune system.
Figure 2: Diet, fatty acids and the actions of anti-inflammatory GPCRs.

References

  1. 1

    Turnbaugh, P.J. et al. Sci. Transl. Med. 1, 6ra14 (2009).

  2. 2

    De Filippo, C. et al. Proc. Natl. Acad. Sci. USA 107, 14691–14696 (2010).

    Article  Google Scholar 

  3. 3

    Wen, L. et al. Nature 455, 1109–1113 (2008).

    CAS  Article  Google Scholar 

  4. 4

    Maslowski, K.M. et al. Nature 461, 1282–1286 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Clarke, T.B. et al. Nat. Med. 16, 228–231 (2010).

    CAS  Article  Google Scholar 

  6. 6

    Sin, D.D. & Sutherland, E.R. Thorax 63, 1018–1023 (2008).

    CAS  Article  Google Scholar 

  7. 7

    Patterson, C.C. et al. Lancet 373, 2027–2033 (2009).

    Article  Google Scholar 

  8. 8

    Noverr, M.C. & Huffnagle, G.B. Trends Microbiol. 12, 562–568 (2004).

    CAS  Article  Google Scholar 

  9. 9

    Devereux, G. Nat. Rev. Immunol. 6, 869–874 (2006).

    CAS  Article  Google Scholar 

  10. 10

    Duncan, S.H. et al. Appl. Environ. Microbiol. 73, 1073–1078 (2007).

    CAS  Article  Google Scholar 

  11. 11

    Vijay-Kumar, M. et al. Science 328, 228–231 (2010).

    CAS  Article  Google Scholar 

  12. 12

    Kalliomaki, M. et al. J. Allergy Clin. Immunol. 107, 129–134 (2001).

    CAS  Article  Google Scholar 

  13. 13

    Eerola, E. et al. Br. J. Rheumatol. 33, 1030–1038 (1994).

    CAS  Article  Google Scholar 

  14. 14

    Vaahtovuo, J. et al. J. Rheumatol. 35, 1500–1505 (2008).

    CAS  PubMed  Google Scholar 

  15. 15

    Wu, H.J. et al. Immunity 32, 815–827 (2010).

    CAS  Article  Google Scholar 

  16. 16

    Frank, D.N. et al. Proc. Natl. Acad. Sci. USA 104, 13780–13785 (2007).

    CAS  Article  Google Scholar 

  17. 17

    Le Poul, E. et al. J. Biol. Chem. 278, 25481–25489 (2003).

    CAS  Article  Google Scholar 

  18. 18

    Quivy, V. & Van Lint, C. Biochem. Pharmacol. 68, 1221–1229 (2004).

    CAS  Article  Google Scholar 

  19. 19

    Hoverstad, T. & Midtvedt, T. J. Nutr. 116, 1772–1776 (1986).

    CAS  Article  Google Scholar 

  20. 20

    Chervonsky, A.V. Nat. Immunol. 11, 28–35 (2010).

    CAS  Article  Google Scholar 

  21. 21

    Round, J.L. & Mazmanian, S.K. Proc. Natl. Acad. Sci. USA 107, 12204–12209 (2010).

    CAS  Article  Google Scholar 

  22. 22

    Morland, B. & Midtvedt, T. Infect. Immun. 44, 750–752 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. 23

    Slavin, J. Proc. Nutr. Soc. 62, 129–134 (2003).

    CAS  Article  Google Scholar 

  24. 24

    Devereux, G. et al. Am. J. Respir. Crit. Care Med. 174, 499–507 (2006).

    CAS  Article  Google Scholar 

  25. 25

    Galvez, J. et al. Mol. Nutr. Food Res. 49, 601–608 (2005).

    Article  Google Scholar 

  26. 26

    Muller, H. et al. Scand. J. Rheumatol. 30, 1–10 (2001).

    CAS  PubMed  Google Scholar 

  27. 27

    Simopoulos, A.P. J. Am. Coll. Nutr. 21, 495–505 (2002).

    CAS  Article  Google Scholar 

  28. 28

    Oh da, Y. et al. Cell 142, 687–698 (2010).

    Article  Google Scholar 

  29. 29

    Strachan, D.P. Thorax 55 Suppl 1, S2–S10 (2000).

    Article  Google Scholar 

  30. 30

    Khoruts, A. et al. J. Clin. Gastroenterol. 44, 354–360 (2010).

    PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Charles R Mackay.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Maslowski, K., Mackay, C. Diet, gut microbiota and immune responses. Nat Immunol 12, 5–9 (2011). https://doi.org/10.1038/ni0111-5

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing