Diet, gut microbiota and immune responses

The fields of immunology, microbiology, nutrition and metabolism are rapidly converging. Here we expand on a diet-microbiota model as the basis for the greater incidence of asthma and autoimmunity in developed countries.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Diet, microbial composition and regulation of the immune system.
Figure 2: Diet, fatty acids and the actions of anti-inflammatory GPCRs.

References

  1. 1

    Turnbaugh, P.J. et al. Sci. Transl. Med. 1, 6ra14 (2009).

  2. 2

    De Filippo, C. et al. Proc. Natl. Acad. Sci. USA 107, 14691–14696 (2010).

  3. 3

    Wen, L. et al. Nature 455, 1109–1113 (2008).

  4. 4

    Maslowski, K.M. et al. Nature 461, 1282–1286 (2009).

  5. 5

    Clarke, T.B. et al. Nat. Med. 16, 228–231 (2010).

  6. 6

    Sin, D.D. & Sutherland, E.R. Thorax 63, 1018–1023 (2008).

  7. 7

    Patterson, C.C. et al. Lancet 373, 2027–2033 (2009).

  8. 8

    Noverr, M.C. & Huffnagle, G.B. Trends Microbiol. 12, 562–568 (2004).

  9. 9

    Devereux, G. Nat. Rev. Immunol. 6, 869–874 (2006).

  10. 10

    Duncan, S.H. et al. Appl. Environ. Microbiol. 73, 1073–1078 (2007).

  11. 11

    Vijay-Kumar, M. et al. Science 328, 228–231 (2010).

  12. 12

    Kalliomaki, M. et al. J. Allergy Clin. Immunol. 107, 129–134 (2001).

  13. 13

    Eerola, E. et al. Br. J. Rheumatol. 33, 1030–1038 (1994).

  14. 14

    Vaahtovuo, J. et al. J. Rheumatol. 35, 1500–1505 (2008).

  15. 15

    Wu, H.J. et al. Immunity 32, 815–827 (2010).

  16. 16

    Frank, D.N. et al. Proc. Natl. Acad. Sci. USA 104, 13780–13785 (2007).

  17. 17

    Le Poul, E. et al. J. Biol. Chem. 278, 25481–25489 (2003).

  18. 18

    Quivy, V. & Van Lint, C. Biochem. Pharmacol. 68, 1221–1229 (2004).

  19. 19

    Hoverstad, T. & Midtvedt, T. J. Nutr. 116, 1772–1776 (1986).

  20. 20

    Chervonsky, A.V. Nat. Immunol. 11, 28–35 (2010).

  21. 21

    Round, J.L. & Mazmanian, S.K. Proc. Natl. Acad. Sci. USA 107, 12204–12209 (2010).

  22. 22

    Morland, B. & Midtvedt, T. Infect. Immun. 44, 750–752 (1984).

  23. 23

    Slavin, J. Proc. Nutr. Soc. 62, 129–134 (2003).

  24. 24

    Devereux, G. et al. Am. J. Respir. Crit. Care Med. 174, 499–507 (2006).

  25. 25

    Galvez, J. et al. Mol. Nutr. Food Res. 49, 601–608 (2005).

  26. 26

    Muller, H. et al. Scand. J. Rheumatol. 30, 1–10 (2001).

  27. 27

    Simopoulos, A.P. J. Am. Coll. Nutr. 21, 495–505 (2002).

  28. 28

    Oh da, Y. et al. Cell 142, 687–698 (2010).

  29. 29

    Strachan, D.P. Thorax 55 Suppl 1, S2–S10 (2000).

  30. 30

    Khoruts, A. et al. J. Clin. Gastroenterol. 44, 354–360 (2010).

Download references

Author information

Correspondence to Charles R Mackay.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Maslowski, K., Mackay, C. Diet, gut microbiota and immune responses. Nat Immunol 12, 5–9 (2011). https://doi.org/10.1038/ni0111-5

Download citation

Further reading