ZAPS electrifies RIG-I signaling

ZAPS, a member of the poly(ADP-ribose) polymerase family, modulates innate antiviral immunity by boosting signaling of the RNA helicase RIG-I.

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Figure 1: Model of the regulation of RIG-I antiviral activity and the innate immune response by ZAPS.

References

  1. 1

    Yoneyama, M. & Fujita, T. Immunol. Rev. 227, 54–65 (2009).

    CAS  Article  Google Scholar 

  2. 2

    Schreiber, V., Dantzer, F., Ame, J.C. & de Murcia, G. Nat. Rev. Mol. Cell Biol. 7, 517–528 (2006).

    CAS  Article  Google Scholar 

  3. 3

    Hayakawa, S. Nat. Immunol. 12, 37–44 (2011).

    CAS  Article  Google Scholar 

  4. 4

    Loo, Y.M. & Gale, M., Jr. Curr. Top. Microbiol. Immunol. 316, 295–313 (2007).

    CAS  PubMed  Google Scholar 

  5. 5

    Gao, G., Guo, X. & Goff, S.P. Science 297, 1703–1706 (2002).

    CAS  Article  Google Scholar 

  6. 6

    Hakme, A., Wong, H.K., Dantzer, F. & Schreiber, V. EMBO Rep. 9, 1094–1100 (2008).

    CAS  Article  Google Scholar 

  7. 7

    Chen, G., Guo, X., Lv, F., Xu, Y. & Gao, G. Proc. Natl. Acad. Sci. USA 105, 4352–4357 (2008).

    CAS  Article  Google Scholar 

  8. 8

    Friedman, C.S. et al. EMBO Rep. 9, 930–936 (2008).

    CAS  Article  Google Scholar 

  9. 9

    Nistal-Villan, E. et al. J. Biol. Chem. 285, 20252–20261 (2010).

    CAS  Article  Google Scholar 

  10. 10

    Arimoto, K., Konishi, H. & Shimotohno, K. Mol. Immunol. 45, 1078–1084 (2008).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Michael Gale Jr.

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Liu, H., Gale, M. ZAPS electrifies RIG-I signaling. Nat Immunol 12, 11–12 (2011). https://doi.org/10.1038/ni0111-11

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