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IRF1: a deus ex machina in TH1 differentiation

Nature Immunology volume 9, pages 9–10 (2008)Cite this article

The cytokines IFN-γ and IL-12, along with the transcription factors STAT4 and T-bet, are necessary for driving TH1 development. Fresh data now indicate that the transcription factor IRF1 is also essential in this process.

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Figure 1: IRF1 is essential for the differentiation of naive T cells into TH1 but not TH-17 cells.

Katie Ris-Vicari

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Authors and Affiliations

  1. Derya Unutmaz and Jan Vilcek are in the Department of Microbiology, New York University Medical Center, New York, New York 10016, USA. jan.vilcek@med.nyu.edu,

    Derya Unutmaz & Jan Vilcek

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  1. Derya Unutmaz
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  2. Jan Vilcek
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Unutmaz, D., Vilcek, J. IRF1: a deus ex machina in TH1 differentiation. Nat Immunol 9, 9–10 (2008). https://doi.org/10.1038/ni0108-9

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