In their own defense, tissues send a panoply of signals that initiate immunity and guide the choice of effector class. TH1-TH2 and Treg is far too simple a representation of the breathtaking variety of the resulting responses.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Pregnancy, a test case for immunology
Synthese Open Access 04 January 2024
-
Salidroside regulates tumor microenvironment of non-small cell lung cancer via Hsp70/Stub1/Foxp3 pathway in Tregs
BMC Cancer Open Access 01 August 2023
-
Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s
Scientific Reports Open Access 23 June 2021
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Janeway, C.A. Jr., Immunol. Today 13, 11–16 (1992).
Matzinger, P. Annu. Rev. Immunol. 12, 991–1045 (1994).
Matzinger, P. Science 296, 301–305 (2002).
Seong, S. & Matzinger, P. Nat. Rev. Immunol. 4, 469–478 (2004).
Takabayshi, K. et al. Immunity 24, 475–487 (2006).
Johansson, C. & Kelsall, B.L. Semin. Immunol. 17, 284–294 (2005).
Zamiri, P., Masli, S., Streilein, J.W. & Taylor, A.W. Invest. Ophthalmol. Vis. Sci. 47, 3912–3918 (2006).
Havran, W.L., Jameson, J.M. & Witherden, D.A. Am. J. Physiol. Gastrointest. Liver Physiol. 289, G627–G630 (2005).
Hayday, A., Theodoridis, E., Ramsburg, E. & Shires, J. Nat. Immunol. 2, 997–1003 (2001).
Bendelac, A., Bonneville, M. & Kearney, J.F. Nat. Rev. Immunol. 1, 177–186 (2001).
Moffett, A. & Loke, C. Nat. Rev. Immunol. 6, 584–594 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Matzinger, P. Friendly and dangerous signals: is the tissue in control?. Nat Immunol 8, 11–13 (2007). https://doi.org/10.1038/ni0107-11
Issue Date:
DOI: https://doi.org/10.1038/ni0107-11
This article is cited by
-
Pregnancy, a test case for immunology
Synthese (2024)
-
Salidroside regulates tumor microenvironment of non-small cell lung cancer via Hsp70/Stub1/Foxp3 pathway in Tregs
BMC Cancer (2023)
-
From purines to purinergic signalling: molecular functions and human diseases
Signal Transduction and Targeted Therapy (2021)
-
Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s
Scientific Reports (2021)
-
Encapsulation Strategies for Pancreatic Islet Transplantation without Immune Suppression
Current Stem Cell Reports (2021)