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Dendritic cells: a journey from laboratory to clinic

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Dendritic cell–based vaccines have been rapidly transferred from the laboratory to the clinic. As the full potential of these cells has not yet been entirely exploited, many strategies could improve the immunogenicity of these vaccines.

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References

  1. 1

    Banchereau, J. & Steinman, R.M. Nature 392, 245–252 (1998).

  2. 2

    Hsu, F.J. et al. Nat. Med. 2, 52–58 (1996).

  3. 3

    Schuler, G., Schuler-Thurner, B. & Steinman, R.M. Curr. Opin. Immunol. 15, 138–147 (2003).

  4. 4

    Thurner, B. et al. J. Exp. Med. 190, 1669–1678 (1999).

  5. 5

    Banchereau, J. et al. Cancer Res. 61, 6451–6458 (2001).

  6. 6

    Dhodapkar, M.V. et al. J. Clin. Invest. 104, 173–180 (1999).

  7. 7

    Coulie, P.G. et al. Proc. Natl. Acad. Sci. USA 98, 10290–10295 (2001).

  8. 8

    Karanikas, V. et al. J. Immunol. 171, 4898–4904 (2003).

  9. 9

    Speiser, D.E. et al. Eur. J. Immunol. 32, 731–741 (2002).

  10. 10

    Smith, J.W. et al. J. Clin. Oncol. 21, 1562–1573 (2003).

  11. 11

    Lee, P. et al. J. Clin. Oncol. 19, 3836–3847 (2001).

  12. 12

    Schaed, S.G. et al. Clin. Cancer Res. 8, 967–972 (2002).

  13. 13

    Pullarkat, V. et al. Clin. Cancer Res. 9, 1301–1312 (2003).

  14. 14

    Lee, K.H. et al. J. Immunol. 163, 6292–300 (1999).

  15. 15

    Salio, M. et al. Eur. J. Immunol. 33, 1052–1062 (2003).

  16. 16

    Le Bon, A. et al. Nat. Immunol. 4, 1009–1015 (2003).

  17. 17

    Lanzavecchia, A. & Sallusto, F. Nat. Rev. Immunol. 2, 982–987 (2002).

  18. 18

    Fujii, S., Shimizu, K., Smith, C., Bonifaz, L. & Steinman, R.M. J. Exp. Med. 198, 267–279 (2003).

  19. 19

    Hermans, I.F. et al. J. Immunol. 171, 5140–5147 (2003).

  20. 20

    Palmowski, M.J. et al. J. Immunol. 168, 4391–4398 (2002).

  21. 21

    Schuler-Thurner, B. et al. J. Exp. Med. 195, 1279–12788 (2002).

  22. 22

    Martin-Fontecha, A. et al. J. Exp. Med. 198, 615–621 (2003).

  23. 23

    Itano, A.A. et al. Immunity 19, 47–57 (2003).

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Acknowledgements

We thank G. Schuler, P. Coulie, P. Romero, C. Smith and M. Palmowski for comments on this manuscript.

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Correspondence to Vincenzo Cerundolo.

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Figure 1: Vaccine-driven priming of antigen-specific T cells in the lymph node.

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