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Response to 'A cancer immunosurveillance controversy'

Nature Immunology volume 5, pages 4–5 (2004)Cite this article

Schreiber et al. reply:

Qin and Blankenstein argue that there is insufficient evidence to revive the cancer immunosurveillance hypothesis. However, three lines of evidence strongly support its existence in mice1 (Supplementary Table 1 online). Specifically, immunocompromised mice develop more carcinogen-induced tumors than do immunocompetent mice; carcinogen-induced tumors from immunodeficient mice are more immunogenic than those from immunocompetent mice; and immunocompromised mice develop more spontaneous tumors and lymphomas than do normal mice.

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Acknowledgements

We thank E. Unanue (Washington University) M. Girardi (Yale University) and Schreiber lab members at Washington University, particularly G. Dunn, C. Koebel, H. Ikeda, B. Weaver, B. Judd and K. Sheehan for critical comments and suggestions.

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Authors and Affiliations

  1. Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave., St. Louis, 63110, Missouri, USA

    Robert D Schreiber

  2. Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, New York, 10021, New York, USA

    Lloyd J Old

  3. Peter Gorer Department of Immunobiology, Guy's, King's and St. Thomas Medical School, King's College, London, 2nd Floor New Guy's House, Guy's Hospital, London, SE1 9RT, UK

    Adrian C Hayday

  4. Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett St., East Melbourne, 8006, Victoria, Australia

    Mark J Smyth

Authors
  1. Robert D Schreiber
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  2. Lloyd J Old
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  3. Adrian C Hayday
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  4. Mark J Smyth
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Schreiber, R., Old, L., Hayday, A. et al. Response to 'A cancer immunosurveillance controversy'. Nat Immunol 5, 4–5 (2004). https://doi.org/10.1038/ni0104-4

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