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Feeling stressed? It might be your T cells

A Publisher Correction to this article was published on 28 June 2018

Abolishing signals mediated by the inhibitory receptor PD-1 results in a systemic decrease in tryptophan and tyrosine, which leads to a striking deficiency in the neurotransmitters serotonin and dopamine in the brain and anxiety-like behavior and exacerbated fear.

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Figure 1: Compromising CNS functions by PD-1 ablation.

Kim Caesar/Springer Nature

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Correspondence to Vassiliki A Boussiotis.

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V.A.B. holds patents on the PD-1 pathway licensed by Bristol-Myers Squibb, Roche, Merck, EMDSerono, Boehringer Ingelheim, AstraZeneca, Novartis and Dako.

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Strauss, L., Patsoukis, N. & Boussiotis, V. Feeling stressed? It might be your T cells. Nat Immunol 18, 1281–1283 (2017). https://doi.org/10.1038/ni.3872

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