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Feeling stressed? It might be your T cells

A Publisher Correction to this article was published on 28 June 2018

Abolishing signals mediated by the inhibitory receptor PD-1 results in a systemic decrease in tryptophan and tyrosine, which leads to a striking deficiency in the neurotransmitters serotonin and dopamine in the brain and anxiety-like behavior and exacerbated fear.

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Figure 1: Compromising CNS functions by PD-1 ablation.

Kim Caesar/Springer Nature


  1. 1

    Repasky, E.A., Eng, J. & Hylander, B.L. Cancer J. 21, 97–103 (2015).

    CAS  Article  Google Scholar 

  2. 2

    Glaser, R. & Kiecolt-Glaser, J.K. Natl. Rev. 5, 243–251 (2005).

    CAS  Article  Google Scholar 

  3. 3

    Miyajima, M. et al. Nat. Immunol. 18, 1342–1352 (2017).

    CAS  Article  Google Scholar 

  4. 4

    MacIver, N.J., Michalek, R.D. & Rathmell, J.C. Annu. Rev. Immunol. 31, 259–283 (2013).

    CAS  Article  Google Scholar 

  5. 5

    Patsoukis, N. et al. Nat. Commun. 6, 6692 (2015).

    CAS  Article  Google Scholar 

  6. 6

    Bengsch, B. et al. Immunity 45, 358–373 (2016).

    CAS  Article  Google Scholar 

  7. 7

    Palmiter, R.D. Ann. NY Acad. Sci. 1129, 35–46 (2008).

    CAS  Article  Google Scholar 

  8. 8

    Mosienko, V. et al. Transl. Psychiatry 2, e122 (2012).

    CAS  Article  Google Scholar 

  9. 9

    Sinclair, L.V. et al. Nat. Immunol. 14, 500–508 (2013).

    CAS  Article  Google Scholar 

  10. 10

    Carr, E.L. et al. J. Immunol. 185, 1037–1044 (2010).

    CAS  Article  Google Scholar 

  11. 11

    Nakaya, M. et al. Immunity 40, 692–705 (2014).

    CAS  Article  Google Scholar 

  12. 12

    Zitvogel, L., Kepp, O. & Kroemer, G. Nat. Rev. Clin. Oncol. 8, 151–160 (2011).

    CAS  Article  Google Scholar 

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Correspondence to Vassiliki A Boussiotis.

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Competing interests

V.A.B. holds patents on the PD-1 pathway licensed by Bristol-Myers Squibb, Roche, Merck, EMDSerono, Boehringer Ingelheim, AstraZeneca, Novartis and Dako.

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Strauss, L., Patsoukis, N. & Boussiotis, V. Feeling stressed? It might be your T cells. Nat Immunol 18, 1281–1283 (2017).

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