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IFN-λ 'guts' neutrophil-mediated inflammation

Interferon-λ (IFN-λ) curbs neutrophil-mediated intestinal inflammation by diminishing the production of reactive oxygen species and subsequent oxidative stress. This regulatory process is unique to IFN-λ and is independent of interferon-induced transcription and translation programs.

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Figure 1: IFN-λ produced in response to enteric viruses regulates intestinal inflammation via diminishing neutrophil function.

Kim Caesar/Springer Nature


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Correspondence to Ram Savan.

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Hemann, E., Schwerk, J. & Savan, R. IFN-λ 'guts' neutrophil-mediated inflammation. Nat Immunol 18, 1061–1062 (2017).

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