Biomarkers of chronic inflammation in disease development and prevention: challenges and opportunities

The US National Institutes of Health convened a workshop on disease-promoting chronic inflammation to identify the challenges and needs in the development of clinically feasible strategies for monitoring a person's inflammation status before, during and after disease occurrence.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: CI is associated with low-grade, persistent physiological responses that can lead to tissue degeneration and a variety of diseases.

Debbie Maizels/Springer Nature


  1. 1

    Ashley, N.T., Weil, Z.M. & Nelson, R. Annu. Rev. Ecol. Evol. Syst. 43, 385–406 (2012).

    Article  Google Scholar 

  2. 2

    Goldberg, E.L. & Dixit, V.D. Immunol. Rev. 265, 63–74 (2015).

    CAS  Article  Google Scholar 

  3. 3

    Wiley, C.D. & Campisi, J. Cell Metab. 23, 1013–1021 (2016).

    CAS  Article  Google Scholar 

  4. 4

    Dzutsev, A. et al. Annu. Rev. Immunol. 35, 199–228 (2017).

    CAS  Article  Google Scholar 

  5. 5

    Kannan, S. et al. Sci. Transl. Med. 4, 130ra146 (2012).

    Article  Google Scholar 

  6. 6

    Lamont, R.J. & Hajishengallis, G. Trends Mol. Med. 21, 172–183 (2015).

    CAS  Article  Google Scholar 

  7. 7

    Martins, M.D. et al. J. Dent. Res. 95, 215–222 (2016).

    CAS  Article  Google Scholar 

  8. 8

    Morrison, L. et al. BMC Cancer 16, 80 (2016).

    Article  Google Scholar 

  9. 9

    Varadhan, R. et al. J. Gerontol. A Biol. Sci. Med. Sci. 69, 165–173 (2014).

    CAS  Article  Google Scholar 

  10. 10

    Roy, N.S., Wei, Y., Kuklinski, E. & Asbell, P.A. Invest. Ophthalmol. Vis. Sci. 58, BIO1–BIO19 (2017).

    CAS  Article  Google Scholar 

  11. 11

    Tracy, R.P. et al. J. Am. Heart Assoc. 2, e000117 (2013).

    Article  Google Scholar 

  12. 12

    Kreisl, W.C. et al. Neurobiol. Aging 44, 53–61 (2016).

    CAS  Article  Google Scholar 

  13. 13

    Shin, S.H., Kadayakkara, D.K. & Bulte, J.W. Radiology 282, 194–201 (2017).

    Article  Google Scholar 

  14. 14

    Wang, L.V. & Yao, J. Nat. Methods 13, 627–638 (2016).

    CAS  Article  Google Scholar 

  15. 15

    Abram, T.J. et al. Oral Oncol. 60, 103–111 (2016).

    CAS  Article  Google Scholar 

  16. 16

    Nakagawa, S. et al. Cancer Cell 30, 879–890 (2016).

    CAS  Article  Google Scholar 

  17. 17

    Zierer, J. et al. Sci. Rep. 6, 37646 (2016).

    CAS  Article  Google Scholar 

  18. 18

    Newman, A.B. et al. Int. J. Epidemiol. 45, 1135–1145 (2016).

    Article  Google Scholar 

  19. 19

    Zhen, Y., Chu, C., Zhou, S., Qi, M. & Shu, R. Mol. Med. Rep. 12, 5239–5245 (2015).

    CAS  Article  Google Scholar 

  20. 20

    Hasturk, H. et al. Arterioscler. Thromb. Vasc. Biol. 35, 1123–1133 (2015).

    CAS  Article  Google Scholar 

Download references


We thank the workshop speakers for participating and for providing insight in addressing the challenges associated with biomarker identification and leveraging and developing imaging and sensing technologies, as well as strategies for data integration during chronic inflammatory conditions, and for their time and input in reviewing the manuscript. Workshop organizing committee: Natalie Abram, Danielle Carrick, Paige Green, Richard Mazurchuk, Sudhir Srivastava, Piotr Grodzinski, Grace Shen, Julia Berzhanskaya, Antonello Punturieri, Andrei Kindzelski, Barbara Radziszewska, Felipe Sierra, Ronald Kohanski, Miroslaw Mackiewicz, Francesca Macchiarini, Mercy PrabhuDas, Merriline Vedamony, Preethi Chander, Michelle Hamlet and Johanna Dwyer.

Author information



Corresponding author

Correspondence to Christina H Liu.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Liu, C., Abrams, N., Carrick, D. et al. Biomarkers of chronic inflammation in disease development and prevention: challenges and opportunities. Nat Immunol 18, 1175–1180 (2017).

Download citation

Further reading