Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Meeting Report
  • Published:

Biomarkers of chronic inflammation in disease development and prevention: challenges and opportunities

The US National Institutes of Health convened a workshop on disease-promoting chronic inflammation to identify the challenges and needs in the development of clinically feasible strategies for monitoring a person's inflammation status before, during and after disease occurrence.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: CI is associated with low-grade, persistent physiological responses that can lead to tissue degeneration and a variety of diseases.

Debbie Maizels/Springer Nature


  1. Ashley, N.T., Weil, Z.M. & Nelson, R. Annu. Rev. Ecol. Evol. Syst. 43, 385–406 (2012).

    Article  Google Scholar 

  2. Goldberg, E.L. & Dixit, V.D. Immunol. Rev. 265, 63–74 (2015).

    Article  CAS  Google Scholar 

  3. Wiley, C.D. & Campisi, J. Cell Metab. 23, 1013–1021 (2016).

    Article  CAS  Google Scholar 

  4. Dzutsev, A. et al. Annu. Rev. Immunol. 35, 199–228 (2017).

    Article  CAS  Google Scholar 

  5. Kannan, S. et al. Sci. Transl. Med. 4, 130ra146 (2012).

    Article  Google Scholar 

  6. Lamont, R.J. & Hajishengallis, G. Trends Mol. Med. 21, 172–183 (2015).

    Article  CAS  Google Scholar 

  7. Martins, M.D. et al. J. Dent. Res. 95, 215–222 (2016).

    Article  CAS  Google Scholar 

  8. Morrison, L. et al. BMC Cancer 16, 80 (2016).

    Article  Google Scholar 

  9. Varadhan, R. et al. J. Gerontol. A Biol. Sci. Med. Sci. 69, 165–173 (2014).

    Article  CAS  Google Scholar 

  10. Roy, N.S., Wei, Y., Kuklinski, E. & Asbell, P.A. Invest. Ophthalmol. Vis. Sci. 58, BIO1–BIO19 (2017).

    Article  CAS  Google Scholar 

  11. Tracy, R.P. et al. J. Am. Heart Assoc. 2, e000117 (2013).

    Article  Google Scholar 

  12. Kreisl, W.C. et al. Neurobiol. Aging 44, 53–61 (2016).

    Article  CAS  Google Scholar 

  13. Shin, S.H., Kadayakkara, D.K. & Bulte, J.W. Radiology 282, 194–201 (2017).

    Article  Google Scholar 

  14. Wang, L.V. & Yao, J. Nat. Methods 13, 627–638 (2016).

    Article  CAS  Google Scholar 

  15. Abram, T.J. et al. Oral Oncol. 60, 103–111 (2016).

    Article  CAS  Google Scholar 

  16. Nakagawa, S. et al. Cancer Cell 30, 879–890 (2016).

    Article  CAS  Google Scholar 

  17. Zierer, J. et al. Sci. Rep. 6, 37646 (2016).

    Article  CAS  Google Scholar 

  18. Newman, A.B. et al. Int. J. Epidemiol. 45, 1135–1145 (2016).

    Article  Google Scholar 

  19. Zhen, Y., Chu, C., Zhou, S., Qi, M. & Shu, R. Mol. Med. Rep. 12, 5239–5245 (2015).

    Article  CAS  Google Scholar 

  20. Hasturk, H. et al. Arterioscler. Thromb. Vasc. Biol. 35, 1123–1133 (2015).

    Article  CAS  Google Scholar 

Download references


We thank the workshop speakers for participating and for providing insight in addressing the challenges associated with biomarker identification and leveraging and developing imaging and sensing technologies, as well as strategies for data integration during chronic inflammatory conditions, and for their time and input in reviewing the manuscript. Workshop organizing committee: Natalie Abram, Danielle Carrick, Paige Green, Richard Mazurchuk, Sudhir Srivastava, Piotr Grodzinski, Grace Shen, Julia Berzhanskaya, Antonello Punturieri, Andrei Kindzelski, Barbara Radziszewska, Felipe Sierra, Ronald Kohanski, Miroslaw Mackiewicz, Francesca Macchiarini, Mercy PrabhuDas, Merriline Vedamony, Preethi Chander, Michelle Hamlet and Johanna Dwyer.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Christina H Liu.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, C., Abrams, N., Carrick, D. et al. Biomarkers of chronic inflammation in disease development and prevention: challenges and opportunities. Nat Immunol 18, 1175–1180 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing