Langerhans cells (LCs) are epidermis-resident antigen-presenting cells that share a common ontogeny with macrophages but function as dendritic cells (DCs). Their development, recruitment and retention in the epidermis is orchestrated by interactions with keratinocytes through multiple mechanisms. LC and dermal DC subsets often show functional redundancy, but LCs are required for specific types of adaptive immune responses when antigen is concentrated in the epidermis. This Review will focus on those developmental and functional properties that are unique to LCs.
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Supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the US National Institutes of Health (R01AR060744, R01AR067187, and R01AR071720). We would like to apologize to all authors whose work was not cited or discussed in depth. Given the length limitation, we were unable to be comprehensive in this review.
The author declares no competing financial interests.
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Kaplan, D. Ontogeny and function of murine epidermal Langerhans cells. Nat Immunol 18, 1068–1075 (2017). https://doi.org/10.1038/ni.3815
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