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Myelopoiesis embraces its inner weakness

Nature Immunology volume 18, pages 953954 (2017) | Download Citation

The ability to expand and contract populations of myeloid and lymphoid cells during emergency hematopoiesis helps shape the immune response. The expression of intracellular and soluble forms of osteopontin regulates apoptosis thresholds differently in myeloid cells and lymphoid cells to counter infection.

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Author information

Affiliations

  1. Motti Gerlic is in the Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

    • Motti Gerlic
  2. Ben A Croker is in the Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA, and the Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

    • Ben A Croker

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Motti Gerlic or Ben A Croker.

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DOI

https://doi.org/10.1038/ni.3814

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