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Myelopoiesis embraces its inner weakness

The ability to expand and contract populations of myeloid and lymphoid cells during emergency hematopoiesis helps shape the immune response. The expression of intracellular and soluble forms of osteopontin regulates apoptosis thresholds differently in myeloid cells and lymphoid cells to counter infection.

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Figure 1: iOPN shapes emergency myelopoiesis.

Debbie Maizels/Springer Nature

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Correspondence to Motti Gerlic or Ben A Croker.

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Gerlic, M., Croker, B. Myelopoiesis embraces its inner weakness. Nat Immunol 18, 953–954 (2017). https://doi.org/10.1038/ni.3814

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