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MLL4 keeps Foxp3 in the loop

Nature Immunology volume 18, pages 957–958 (2017)Cite this article

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The histone lysine methyltransferase MLL4 primes the locus encoding the transcription factor Foxp3 for transcriptional activation in thymus-derived and inducible regulatory T cells.

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Figure 1: MLL4 primes the Foxp3 locus for transcriptional activation in Treg cells.

References

  1. Sakaguchi, S., Vignali, D.A., Rudensky, A.Y., Niec, R.E. & Waldmann, H. Nat. Rev. Immunol. 13, 461–467 (2013).

    Article  CAS  Google Scholar 

  2. Delacher, M. et al. Curr. Top. Microbiol. Immunol. 381, 83–124 (2014).

    PubMed  Google Scholar 

  3. Kitagawa, Y. et al. Nat. Immunol. 18, 173–183 (2017).

    Article  CAS  Google Scholar 

  4. Placek, K. et al. Nat Immunol. 18, 1035–1045 (2017).

    Article  CAS  Google Scholar 

  5. Rao, R.C. & Dou, Y. Nat. Rev. Cancer 15, 334–346 (2015).

    Article  CAS  Google Scholar 

  6. Calo, E. & Wysocka, J. Mol. Cell 49, 825–837 (2013).

    Article  CAS  Google Scholar 

  7. Hnisz, D. et al. Cell 155, 934–947 (2013).

    Article  CAS  Google Scholar 

  8. Li, X. & Zheng, Y. Trends Immunol. 36, 344–353 (2015).

    Article  CAS  Google Scholar 

  9. Josefowicz, S.Z., Wilson, C.B. & Rudensky, A.Y. J. Immunol. 182, 6648–6652 (2009).

    Article  CAS  Google Scholar 

  10. Xing, S. et al. Nat. Immunol. 17, 695–703 (2016).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Internal Medicine, Iowa City Veteran Affairs Health Care Systems, Iowa City, Iowa, USA

    Dong-Mei Zhao

  2. Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

    Hai-Hui Xue

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  1. Dong-Mei Zhao
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  2. Hai-Hui Xue
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Correspondence to Hai-Hui Xue.

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Zhao, DM., Xue, HH. MLL4 keeps Foxp3 in the loop. Nat Immunol 18, 957–958 (2017). https://doi.org/10.1038/ni.3811

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