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Fat T cells go to the joint

Poor glycolysis and increased fatty-acid synthesis feed the locomotion machinery in T cells from people with rheumatoid arthritis and allow these cells to enter the synovium and propagate joint inflammation and destruction.

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Figure 1: Metabolic rewiring of RA T cells enables them to enter the synovium.

Debbie Maizels/Springer Nature

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Correspondence to George C Tsokos.

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Tsokos, G. Fat T cells go to the joint. Nat Immunol 18, 955–956 (2017). https://doi.org/10.1038/ni.3810

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