Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A guiding map for inflammation

An Author Correction to this article was published on 07 December 2020

This article has been updated

Abstract

Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The immunological mechanisms leading to the induction of inflammation during the first stages of host defense against invading pathogens.

Debbie Maizels/Springer Nature

Figure 2: The regulatory mechanisms that modulate inflammation and lead to resolution after the elimination of invading pathogens.

Debbie Maizels/Springer Nature

Change history

  • 07 December 2020

    A Correction to this paper has been published: https://doi.org/10.1038/ni.3790

References

  1. 1

    Eltzschig, H.K. & Carmeliet, P. N. Engl. J. Med. 364, 656–665 (2011).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. 2

    Franceschi, C. & Campisi, J. J. Gerontol. A Biol. Sci. Med. Sci. 69 (Suppl. 1), S4–S9 (2014).

    PubMed  Google Scholar 

  3. 3

    Akira, S., Uematsu, S. & Takeuchi, O. Cell 124, 783–801 (2006).

    CAS  PubMed  Google Scholar 

  4. 4

    Iwasaki, A. & Medzhitov, R. Nat. Immunol. 5, 987–995 (2004).

    CAS  PubMed  Google Scholar 

  5. 5

    Dinarello, C.A. Eur. J. Immunol. 37 (Suppl. 1), S34–S45 (2007).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. 6

    Dinarello, C.A. Curr. Top. Microbiol. Immunol. 216, 133–165 (1996).

    CAS  PubMed  Google Scholar 

  7. 7

    Bonecchi, R. et al. Front. Biosci. (Landmark Ed.) 14, 540–551 (2009).

    CAS  Google Scholar 

  8. 8

    Scapini, P., Marini, O., Tecchio, C. & Cassatella, M.A. Immunol. Rev. 273, 48–60 (2016).

    CAS  PubMed  Google Scholar 

  9. 9

    Eyerich, K., Dimartino, V. & Cavani, A. Eur. J. Immunol. 47, 607–614 (2017).

    CAS  PubMed  Google Scholar 

  10. 10

    Artis, D. & Spits, H. Nature 517, 293–301 (2015).

    CAS  PubMed  Google Scholar 

  11. 11

    Shattuck, E.C. & Muehlenbein, M.P. Am. J. Phys. Anthropol. 157, 1–18 (2015).

    PubMed  Google Scholar 

  12. 12

    Ward, P.A. J. Innate Immun. 2, 439–445 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. 13

    Ouyang, W., Rutz, S., Crellin, N.K., Valdez, P.A. & Hymowitz, S.G. Annu. Rev. Immunol. 29, 71–109 (2011).

    CAS  PubMed  Google Scholar 

  14. 14

    Dinarello, C.A. et al. Eur. J. Immunol. 46, 1067–1081 (2016).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. 15

    Dinarello, C.A. Eur. J. Immunol. 40, 599–606 (2010).

    CAS  PubMed  Google Scholar 

  16. 16

    Blom, A.M. J. Intern. Med. http://dx.doi.org/10.1111/joim.12606 (2017).

  17. 17

    Joosten, L.A. et al. Ann. Rheum. Dis. 75, 1219–1227 (2016).

    CAS  PubMed  Google Scholar 

  18. 18

    Andersson, U. & Tracey, K.J. Annu. Rev. Immunol. 30, 313–335 (2012).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. 19

    Hotchkiss, R.S., Monneret, G. & Payen, D. Nat. Rev. Immunol. 13, 862–874 (2013).

    CAS  PubMed  PubMed Central  Google Scholar 

  20. 20

    Singer, M. et al. J. Am. Med. Assoc. 315, 801–810 (2016).

    CAS  Google Scholar 

  21. 21

    Takeuchi, O. & Akira, S. Cell 140, 805–820 (2010).

    CAS  PubMed  Google Scholar 

  22. 22

    Cohen, J. et al. Lancet Infect. Dis. 15, 581–614 (2015).

    PubMed  Google Scholar 

  23. 23

    van der Poll, T., van de Veerdonk, F.L., Scicluna, B.P. & Netea, M.G. Nat. Rev. Immunol. http://dx.doi.org/10.1038/nri.2017.36 (2017).

  24. 24

    Bamias, G., Pizarro, T.T. & Cominelli, F. Transl. Res. 167, 104–115 (2016).

    PubMed  Google Scholar 

  25. 25

    Firestein, G.S. & McInnes, I.B. Immunity 46, 183–196 (2017).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. 26

    Englbrecht, M. et al. Arthritis Care Res. (Hoboken) 62, 977–983 (2010).

    CAS  Google Scholar 

  27. 27

    Sutton, C., Brereton, C., Keogh, B., Mills, K.H. & Lavelle, E.C. J. Exp. Med. 203, 1685–1691 (2006).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. 28

    Robbins, C.S. et al. Nat. Med. 19, 1166–1172 (2013).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. 29

    Duewell, P. et al. Nature 464, 1357–1361 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

  30. 30

    Ketelhuth, D.F. & Hansson, G.K. Circ. Res. 118, 668–678 (2016).

    CAS  PubMed  Google Scholar 

  31. 31

    Heneka, M.T., Golenbock, D.T. & Latz, E. Nat. Immunol. 16, 229–236 (2015).

    CAS  PubMed  Google Scholar 

  32. 32

    Heneka, M.T., Kummer, M.P. & Latz, E. Nat. Rev. Immunol. 14, 463–477 (2014).

    CAS  PubMed  Google Scholar 

  33. 33

    Kettenmann, H., Hanisch, U.K., Noda, M. & Verkhratsky, A. Physiol. Rev. 91, 461–553 (2011).

    CAS  PubMed  Google Scholar 

  34. 34

    Halle, A. et al. Nat. Immunol. 9, 857–865 (2008).

    CAS  PubMed  PubMed Central  Google Scholar 

  35. 35

    Pocock, J.M. & Kettenmann, H. Trends Neurosci. 30, 527–535 (2007).

    CAS  PubMed  Google Scholar 

  36. 36

    Cressman, D.E. et al. Science 274, 1379–1383 (1996).

    CAS  PubMed  Google Scholar 

  37. 37

    Mastrandrea, L. et al. Diabetes Care 32, 1244–1249 (2009).

    CAS  PubMed  PubMed Central  Google Scholar 

  38. 38

    Moran, A. et al. Lancet 381, 1905–1915 (2013).

    CAS  PubMed  Google Scholar 

  39. 39

    Larsen, C.M. et al. N. Engl. J. Med. 356, 1517–1526 (2007).

    CAS  PubMed  Google Scholar 

  40. 40

    Donath, M.Y. Nat. Rev. Drug Discov. 13, 465–476 (2014).

    CAS  PubMed  Google Scholar 

  41. 41

    Lambrecht, B.N. & Hammad, H. Nat. Med. 18, 684–692 (2012).

    CAS  PubMed  Google Scholar 

  42. 42

    Gupta, J. et al. Clin. J. Am. Soc. Nephrol. 7, 1938–1946 (2012).

    CAS  PubMed  PubMed Central  Google Scholar 

  43. 43

    Tonelli, M., Sacks, F., Pfeffer, M., Jhangri, G.S. & Curhan, G. Kidney Int. 68, 237–245 (2005).

    CAS  PubMed  Google Scholar 

  44. 44

    Burns, K.D. Kidney Int. 62, 346–347 (2002).

    PubMed  Google Scholar 

  45. 45

    Nowak, K.L. et al. J. Am. Soc. Nephrol. 28, 971–980 (2017).

    CAS  PubMed  Google Scholar 

  46. 46

    Palmer, C.N. et al. Nat. Genet. 38, 441–446 (2006).

    CAS  PubMed  Google Scholar 

  47. 47

    Noda, S., Krueger, J.G. & Guttman-Yassky, E. J. Allergy Clin. Immunol. 135, 324–336 (2015).

    CAS  PubMed  Google Scholar 

  48. 48

    Kanni, T. et al. PLoS One 10, e0130522 (2015).

    PubMed  PubMed Central  Google Scholar 

  49. 49

    Aksentijevich, I. et al. N. Engl. J. Med. 360, 2426–2437 (2009).

    CAS  PubMed  PubMed Central  Google Scholar 

  50. 50

    Manthiram, K., Zhou, Q., Aksentijevich, I. & Kastner, D.L. Nat. Immunol. 18, 832–842.

  51. 51

    Balkwill, F. & Mantovani, A. Lancet 357, 539–545 (2001).

    CAS  PubMed  PubMed Central  Google Scholar 

  52. 52

    Mantovani, A., Allavena, P., Sica, A. & Balkwill, F. Nature 454, 436–444 (2008).

    CAS  PubMed  Google Scholar 

  53. 53

    Mantovani, A., Marchesi, F., Malesci, A., Laghi, L. & Allavena, P. Nat. Rev. Clin. Oncol. http://dx.doi.org/10.1038/nrclinonc.2016.217 (2017).

  54. 54

    Gajewski, T.F., Schreiber, H. & Fu, Y.X. Nat. Immunol. 14, 1014–1022 (2013).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We thank all our colleagues in the field for their contributions to knowledge of inflammation. D.L.K. was supported by the Intramural Research Program of the National Human Genome Research Institute (NHGRI) at the US National Institutes of Health. M.G.N. was supported by an ERC Consolidator Grant (no. 310372), a Spinoza Grant from the Netherlands Organization for Scientific Research and a Competitiveness Operational Programme Grant from the Romanian Ministry of European Funds (FUSE). K.L.N. was supported by American Heart Association postdoctoral fellowship award 12POST11920023. F.C. was supported by NIH grants DK042191, DK055812, DK091222 and DK097948. F.B. was supported by an ERC Advanced Grant (ERC322566) and a Cancer Research UK Programme Grant (A16354). C.A.D. was supported by NIH grant AI15614. L.A.J. was supported by a Competitiveness Operational Programme grant from the Romanian Ministry of European Funds (HINT, ID P_37_762; MySMIS 103587) and a Dutch Arthritis Foundation grant (NR-12-2-303). K.H.G.M. was supported by grants from Science Foundation Ireland. P.L. was supported by the RRM Charitable Fund and The National Heart, Lung, and Blood Institute (R01 HL080472). B.S. was supported by the German Research Foundation SPP1656, 749/7-1, 749/10-1, the German Cancer Foundation, the German Israel Foundation and the Horizon 2020 program. D.A.S. was supported by NIH grant R01-HL097163. A.M. was supported by ERC, AIRC and Fondazione Cariplo.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Mihai G Netea.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Netea, M., Balkwill, F., Chonchol, M. et al. A guiding map for inflammation. Nat Immunol 18, 826–831 (2017). https://doi.org/10.1038/ni.3790

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing