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A guiding map for inflammation

Nature Immunology volume 18, pages 826–831 (2017)Cite this article

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An Author Correction to this article was published on 07 December 2020

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Abstract

Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues.

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Figure 1: The immunological mechanisms leading to the induction of inflammation during the first stages of host defense against invading pathogens.

Debbie Maizels/Springer Nature

Figure 2: The regulatory mechanisms that modulate inflammation and lead to resolution after the elimination of invading pathogens.

Debbie Maizels/Springer Nature

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  • 07 December 2020

    A Correction to this paper has been published: https://doi.org/10.1038/ni.3790

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Acknowledgements

We thank all our colleagues in the field for their contributions to knowledge of inflammation. D.L.K. was supported by the Intramural Research Program of the National Human Genome Research Institute (NHGRI) at the US National Institutes of Health. M.G.N. was supported by an ERC Consolidator Grant (no. 310372), a Spinoza Grant from the Netherlands Organization for Scientific Research and a Competitiveness Operational Programme Grant from the Romanian Ministry of European Funds (FUSE). K.L.N. was supported by American Heart Association postdoctoral fellowship award 12POST11920023. F.C. was supported by NIH grants DK042191, DK055812, DK091222 and DK097948. F.B. was supported by an ERC Advanced Grant (ERC322566) and a Cancer Research UK Programme Grant (A16354). C.A.D. was supported by NIH grant AI15614. L.A.J. was supported by a Competitiveness Operational Programme grant from the Romanian Ministry of European Funds (HINT, ID P_37_762; MySMIS 103587) and a Dutch Arthritis Foundation grant (NR-12-2-303). K.H.G.M. was supported by grants from Science Foundation Ireland. P.L. was supported by the RRM Charitable Fund and The National Heart, Lung, and Blood Institute (R01 HL080472). B.S. was supported by the German Research Foundation SPP1656, 749/7-1, 749/10-1, the German Cancer Foundation, the German Israel Foundation and the Horizon 2020 program. D.A.S. was supported by NIH grant R01-HL097163. A.M. was supported by ERC, AIRC and Fondazione Cariplo.

Author information

Authors and Affiliations

  1. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands

    Mihai G Netea, Mark S Gresnigt, Leo A B Joosten, Jos W M van der Meer, Frank L van de Veerdonk & Charles A Dinarello

  2. Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania

    Mihai G Netea

  3. Barts Cancer Institute, Queen Mary University of London, London, UK

    Frances Balkwill

  4. Division of Renal Diseases and Hypertension, University of Colorado, Denver, Aurora, Colorado, USA

    Michel Chonchol & Kristen L Nowak

  5. Digestive Health Research Institute, Case Western Reserve University, Cleveland, Ohio, USA

    Fabio Cominelli

  6. Clinic of Endocrinology, Diabetes and Metabolism, University Hospital, University of Basel, Basel, Switzerland

    Marc Y Donath

  7. 4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Evangelos J Giamarellos-Bourboulis

  8. Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Douglas Golenbock & Eicke Latz

  9. Department of Neurodegenerative Disease and Gerontopsychiatry/Neurology, University of Bonn, Bonn, Germany

    Michael T Heneka

  10. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

    Michael T Heneka & Eicke Latz

  11. Division of Pediatric Allergy, Immunology, and Rheumatology, University of California at San Diego and Rady Children's Hospital of San Diego, San Diego, California, USA

    Hal M Hoffman

  12. Department of Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, St Louis, Missouri, USA

    Richard Hotchkiss

  13. Department of Medical Genetics, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

    Leo A B Joosten

  14. Inflammatory Disease Section, Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA

    Daniel L Kastner

  15. TU Braunschweig, Zoological Institute and HZI, AG NIND, Braunschweig, Germany

    Martin Korte

  16. Institute of Innate Immunity, University Hospital Bonn, University of Bonn, Bonn, Germany

    Eicke Latz

  17. Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

    Peter Libby

  18. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

    Thomas Mandrup-Poulsen

  19. Humanitas Clinica Research Center, Humanitas University, Milano, Italy

    Alberto Mantovani

  20. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

    Kingston H G Mills & Luke A O'Neill

  21. Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

    Peter Pickkers

  22. Division of Infectious Diseases, Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Tom van der Poll

  23. Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Paul M Ridker

  24. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Paul M Ridker

  25. Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands

    Joost Schalkwijk

  26. Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Denver, Aurora, Colorado, USA

    David A Schwartz

  27. Department of Medicine (Gastroenterology, Infectious Diseases, Rheumatology), Charité-Universitätsmedizin Berlin, Berlin, Germany

    Britta Siegmund

  28. Departments of Medicine and of Genetics, Cell Biology and Development, University of Minnesota Medical School, Minneapolis, Minnesota, USA

    Clifford J Steer

  29. Department of Internal Medicine I, Gastroenterology, Hepatology & Endocrinology, Medical University Innsbruck, Innsbruck, Austria

    Herbert Tilg

  30. Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA

    Charles A Dinarello

Authors
  1. Mihai G Netea
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  2. Frances Balkwill
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  32. Charles A Dinarello
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Correspondence to Mihai G Netea.

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Netea, M., Balkwill, F., Chonchol, M. et al. A guiding map for inflammation. Nat Immunol 18, 826–831 (2017). https://doi.org/10.1038/ni.3790

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