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Atypical matters in myeloid differentiation

Nature Immunology volume 18, pages 711–712 (2017)Cite this article

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Chemokines are important components of the hematopoietic niche. The atypical chemokine receptor 1 (ACKR1), expressed on erythrocyte precursors, regulates myeloid differentiation.

The chemokine system regulates the migration of leukocytes from the bone marrow to the tissues and is critical for the correct function of the immune system1. Genetic studies have identified one polymorphism in ACKR1 (previously known as Duffy antigen receptor for chemokines, DARC) as the major genetic determinant of the neutropenia found among healthy people of African descent. Duffy-negative individuals lack ACKR1 expression on erythrocytes2. In this issue of Nature Immunology, Duchene et al. provide a mechanistic link between the Duffy-negative phenotype and the neutropenic state, demonstrating that the absence of ACKR1 in immature erythrocytes (nucleated erythroid cells, NECs) in the bone marrow causes neutropenia, altering hematopoiesis and in particular myeloid differentiation3.

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Figure 1: Role of chemokines and chemokine receptors in the bone marrow hematopoietic niche.

Debbie Maizels/Springer Nature

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Authors and Affiliations

  1. Humanitas Clinical and Research Center and the Department of Biomedical Sciences, Humanitas University, Rozzano, Italy

    Alberto Mantovani & Raffaella Bonecchi

  2. Humanitas Clinical and Research Center, Rozzano, Italy

    Massimo Locati

  3. Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Milano, Italy

    Massimo Locati

Authors
  1. Massimo Locati
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  2. Alberto Mantovani
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  3. Raffaella Bonecchi
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Correspondence to Raffaella Bonecchi.

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Locati, M., Mantovani, A. & Bonecchi, R. Atypical matters in myeloid differentiation. Nat Immunol 18, 711–712 (2017). https://doi.org/10.1038/ni.3776

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