A study of polymorphisms in the sensor IFIH1 exposes the evolutionary trade-off between a robust antiviral type I interferon response and the risk of interferon-mediated inflammation.
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The authors declare no competing financial interests.
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Della Mina, E., Rodero, M. & Crow, Y. Polymorphisms in IFIH1: the good and the bad. Nat Immunol 18, 708–709 (2017). https://doi.org/10.1038/ni.3765