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Polymorphisms in IFIH1: the good and the bad

A study of polymorphisms in the sensor IFIH1 exposes the evolutionary trade-off between a robust antiviral type I interferon response and the risk of interferon-mediated inflammation.

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Figure 1: The common polymorphism p.A946T in IFIH1 has been linked to a variety of autoimmune diseases.

Debbie Maizels/Springer Nature


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Correspondence to Yanick J Crow.

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Della Mina, E., Rodero, M. & Crow, Y. Polymorphisms in IFIH1: the good and the bad. Nat Immunol 18, 708–709 (2017).

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