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Polymorphisms in IFIH1: the good and the bad

Nature Immunology volume 18, pages 708–709 (2017)Cite this article

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A study of polymorphisms in the sensor IFIH1 exposes the evolutionary trade-off between a robust antiviral type I interferon response and the risk of interferon-mediated inflammation.

IFIH1 is a cytosolic sensor of dsRNA that induces an anti-viral type I interferon state. Non-synonymous coding variants of IFIH1 have been associated with various autoimmune phenotypes, most particularly type 1 diabetes (T1D)2,3. In the present study, the authors investigate the rs1990760 allele, which encodes an alanine-to-threonine substitution at position 946 of the protein (p.A946T; called 'IFIH1T946' by the authors), which has an allelic frequency of between 50% and 60% in Europeans and Asians, according to large databases of control subjects.

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Figure 1: The common polymorphism p.A946T in IFIH1 has been linked to a variety of autoimmune diseases.

Debbie Maizels/Springer Nature

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Authors and Affiliations

  1. Laboratory of Neurogenetics and Neuroinflammation, INSERM UMR1163, Institut Imagine, Paris, France

    Erika Della Mina & Mathieu P Rodero

  2. Laboratory of Neurogenetics and Neuroinflammation, INSERM UMR1163, Institut Imagine, Paris, France

    Yanick J Crow

  3. Sorbonne-Paris-Cité, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, Paris, France

    Yanick J Crow

  4. Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK

    Yanick J Crow

Authors
  1. Erika Della Mina
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  2. Mathieu P Rodero
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  3. Yanick J Crow
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Correspondence to Yanick J Crow.

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Della Mina, E., Rodero, M. & Crow, Y. Polymorphisms in IFIH1: the good and the bad. Nat Immunol 18, 708–709 (2017). https://doi.org/10.1038/ni.3765

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