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RNA-binding proteins, the guardians of the marginal zone

Nature Immunology volume 18, pages 595597 (2017) | Download Citation

RNA-binding proteins (RBPs) take control of binary cell-fate 'decisions' and cellular identity in lymphoid organs, as the RBP ZFP36L1 is shown to negatively regulate the stability of the transcription factors KLF2 and IRF8 to control the maintenance, survival and localization of marginal zone B cells.

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Author information

Affiliations

  1. Palaniraja Thandapan, Beatriz Aranda-Orgilles and Iannis Aifantis are in the Department of Pathology; Laura & Isaac Perlmutter Cancer Center, and Helen L. & Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, New York, USA.

    • Palaniraja Thandapani
    • , Beatriz Aranda-Orgilles
    •  & Iannis Aifantis

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Iannis Aifantis.

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DOI

https://doi.org/10.1038/ni.3752

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