The short-chain fatty acids (SCFAs) acetate and butyrate, which are released from specialized diets by gut microbes, protect non-obese diabetic (NOD) mice against insulitis and slow the progression of diabetes.
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References
Mariño, E. et al. Nat. Immunol. 18, 552–562 (2017).
Wen, L. et al. Nature 455, 1109–1113 (2008).
Hyttinen, V., Kaprio, J., Kinnunen, L., Koskenvuo, M. & Tuomilehto, J. Diabetes 52, 1052–1055 (2003).
Kostic, A.D. et al. Cell Host Microbe 17, 260–273 (2015).
Vatanen, T. et al. Cell 165, 842–853 (2016).
Atkinson, M.A., von Herrath, M., Powers, A.C. & Clare-Salzler, M. Diabetes Care 38, 979–988 (2015).
Ziegler, A.G. et al. Mol. Metab. 5, 255–262 (2016).
Trompette, A. et al. Nat. Med. 20, 159–166 (2014).
Canfora, E.E., Jocken, J.W. & Blaak, E.E. Nat. Rev. Endocrinol. 11, 577–591 (2015).
Lakhter, A.J. et al. J. Biol. Chem. 291, 21869–21879 (2016).
Zeng, H. & Chi, H. Trends Immunol. 36, 3–12 (2015).
Martin, F., Oliver, A.M. & Kearney, J.F. Immunity 14, 617–629 (2001).
Song, H. & Cerny, J. J. Exp. Med. 198, 1923–1935 (2003).
Tai, N. et al. J. Exp. Med. 213, 2129–2146 (2016).
Mizuno, M., Noto, D., Kaga, N., Chiba, A. & Miyake, S. PLoS One 12, e0173032 (2017).
Acknowledgements
This work was supported by the NIH (DK092882, DK100500 and P30DK045735 to L.W.), JDRF (F.S.W.; 1-INO-2015-136 to L.W.), ADA (1-14-BS-222 to L.W.), the UK Medical Research Council (MR/K021141/1 to F.S.W.), Diabetes UK (to F.S.W.), the European Foundation for the Study of Diabetes (F.S.W.) and the British Council (F.S.W.).
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Wen, L., Wong, F. Dietary short-chain fatty acids protect against type 1 diabetes. Nat Immunol 18, 484–486 (2017). https://doi.org/10.1038/ni.3730
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DOI: https://doi.org/10.1038/ni.3730
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