News & Views | Published:

Gene-enhancer variants reveal diverse TCR-mediated differentiation

Nature Immunology volume 18, pages 483484 (2017) | Download Citation

The transcription factor IRF4 acts as a 'rheostat' for TCR signaling. Discrete levels of IRF4 can activate distinct transcriptional programs in T cells due to binding sites of variable affinity in groups of target genes.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , & Cell. Mol. Life Sci. 69, 1565–1575 (2012).

  2. 2.

    et al. Nat. Immunol. 18, 563–572 (2017).

  3. 3.

    et al. Nature 460, 405–409 (2009).

  4. 4.

    et al. J. Exp. Med. 207, 933–942 (2010).

  5. 5.

    et al. Nature 490, 502–507 (2012).

  6. 6.

    , & Nat. Rev. Immunol. 13, 499–509 (2013).

  7. 7.

    & Eur. J. Immunol. 44, 1886–1895 (2014).

  8. 8.

    et al. Nat. Genet. 43, 513–518 (2011).

  9. 9.

    & Trends Immunol. 37, 513–522 (2016).

  10. 10.

    & Curr. Opin. Immunol. 25, 120–125 (2013).

  11. 11.

    et al. Science 340, 630–635 (2013).

  12. 12.

    et al. Science 340, 635–639 (2013).

Download references

Author information

Affiliations

  1. Michael P. Gallagher and Leslie J. Berg are in the Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

    • Michael P Gallagher
    •  & Leslie J Berg

Authors

  1. Search for Michael P Gallagher in:

  2. Search for Leslie J Berg in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Leslie J Berg.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/ni.3729

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing