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Gene-enhancer variants reveal diverse TCR-mediated differentiation

Nature Immunology volume 18, pages 483–484 (2017)Cite this article

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The transcription factor IRF4 acts as a 'rheostat' for TCR signaling. Discrete levels of IRF4 can activate distinct transcriptional programs in T cells due to binding sites of variable affinity in groups of target genes.

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Figure 1: Variable TCR signaling and BATF–IRF4 abundance control distinct gene-expression patterns in differentiating T cells.

References

  1. Zehn, D., King, C., Bevan, M.J. & Palmer, E. Cell. Mol. Life Sci. 69, 1565–1575 (2012).

    Article  CAS  Google Scholar 

  2. Iwata, A. et al. Nat. Immunol. 18, 563–572 (2017).

    Article  CAS  Google Scholar 

  3. Schraml, B.U. et al. Nature 460, 405–409 (2009).

    Article  CAS  Google Scholar 

  4. Betz, B.C. et al. J. Exp. Med. 207, 933–942 (2010).

    Article  CAS  Google Scholar 

  5. Tussiwand, R. et al. Nature 490, 502–507 (2012).

    Article  CAS  Google Scholar 

  6. Murphy, T.L., Tussiwand, R. & Murphy, K.M. Nat. Rev. Immunol. 13, 499–509 (2013).

    Article  CAS  Google Scholar 

  7. Huber, M. & Lohoff, M. Eur. J. Immunol. 44, 1886–1895 (2014).

    Article  CAS  Google Scholar 

  8. Freedman, M.L. et al. Nat. Genet. 43, 513–518 (2011).

    Article  CAS  Google Scholar 

  9. Mayya, V. & Dustin, M.L. Trends Immunol. 37, 513–522 (2016).

    Article  CAS  Google Scholar 

  10. Tkach, K. & Altan-Bonnet, G. Curr. Opin. Immunol. 25, 120–125 (2013).

    Article  CAS  Google Scholar 

  11. Buchholz, V.R. et al. Science 340, 630–635 (2013).

    Article  CAS  Google Scholar 

  12. Gerlach, C. et al. Science 340, 635–639 (2013).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Michael P. Gallagher and Leslie J. Berg are in the Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.,

    Michael P Gallagher & Leslie J Berg

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  1. Michael P Gallagher
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  2. Leslie J Berg
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Correspondence to Leslie J Berg.

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Gallagher, M., Berg, L. Gene-enhancer variants reveal diverse TCR-mediated differentiation. Nat Immunol 18, 483–484 (2017). https://doi.org/10.1038/ni.3729

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