IRE1α is a stress sensor that is activated by a high-fat diet. In adipose-tissue macrophages, it serves as a major switch toward pro-inflammatory M1 polarization and thereby contributes to obesity and associated diseases.
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Bujisic, B., Martinon, F. IRE1 gives weight to obesity-associated inflammation. Nat Immunol 18, 479–480 (2017). https://doi.org/10.1038/ni.3725
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DOI: https://doi.org/10.1038/ni.3725