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Epigenetic orchestration of thymic Treg cell development

Nature Immunology volume 18, pages 144146 (2017) | Download Citation

Regulatory T cells develop in the thymus as a distinct lineage of T cells instructed by the lineage-specifying transcription factor Foxp3. Epigenetic imprinting by the genome organizer Satb1 precedes this cell-fate 'decision' during thymocyte development.

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Author information

Affiliations

  1. Marc Beyer is with the Life and Medical Science Institute, University of Bonn, Bonn, Germany, and the Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.

    • Marc Beyer
  2. Jochen Huehn is with the Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

    • Jochen Huehn

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Marc Beyer or Jochen Huehn.

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DOI

https://doi.org/10.1038/ni.3660

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