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Epigenetic orchestration of thymic Treg cell development

Nature Immunology volume 18, pages 144–146 (2017)Cite this article

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Regulatory T cells develop in the thymus as a distinct lineage of T cells instructed by the lineage-specifying transcription factor Foxp3. Epigenetic imprinting by the genome organizer Satb1 precedes this cell-fate 'decision' during thymocyte development.

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Figure 1: Thymic Treg cell development is governed by Satb1-dependent establishment of super-enhancers.

Marina Corral Spence/Springer Nature

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Authors and Affiliations

  1. Marc Beyer is with the Life and Medical Science Institute, University of Bonn, Bonn, Germany, and the Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn, Bonn, Germany.,

    Marc Beyer

  2. Jochen Huehn is with the Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.,

    Jochen Huehn

Authors
  1. Marc Beyer
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  2. Jochen Huehn
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Correspondence to Marc Beyer or Jochen Huehn.

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The authors declare no competing financial interests.

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Beyer, M., Huehn, J. Epigenetic orchestration of thymic Treg cell development. Nat Immunol 18, 144–146 (2017). https://doi.org/10.1038/ni.3660

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