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Is sex bias orchestrated in the skin?

The identification of VGLL3 as a transcription (co-)factor that underlies the sex bias of the human immune system further underscores the relevance of research into this area.

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Figure 1: Complex regulation of the immune response underlies sex bias in the risk of infection and autoimmune diseases.

Marina Corral Spence/Springer Nature

References

  1. Gleicher, N. & Barad, D.H. J. Autoimmun. 28, 1–6 (2007).

    Article  CAS  Google Scholar 

  2. Liang, Y. et al. Nat. Immunol. 18, 152–160 (2017).

    Article  CAS  Google Scholar 

  3. Fish, E.N. Nat. Rev. Immunol. 8, 737–744 (2008).

    Article  CAS  Google Scholar 

  4. Yurkovetskiy, L. et al. Immunity 39, 400–412 (2013).

    Article  CAS  Google Scholar 

  5. Klein, S.L. & Flanagan, K.L. Nat. Rev. Immunol. 16, 626–638 (2016).

    Article  CAS  Google Scholar 

  6. Zuk, M. PLoS Pathog. 5, e1000267 http://dx.doi.org/10.1371/journal.ppat.1000267 (2009).

    Article  Google Scholar 

  7. Nestle, F.O., Di Meglio, P., Qin, J.Z. & Nickoloff, B.J. Nat. Rev. Immunol. 9, 679–691 (2009).

    Article  CAS  Google Scholar 

  8. Gabrielli, A., Avvedimento, E.V. & Krieg, T. N. Engl. J. Med. 360, 1989–2003 (2009).

    Article  CAS  Google Scholar 

  9. Ngo, S.T., Steyn, F.J. & McCombe, P.A. Front. Neuroendocrinol. 35, 347–369 (2014).

    Article  CAS  Google Scholar 

  10. Seillet, C. et al. Blood 119, 454–464 (2012).

    Article  CAS  Google Scholar 

  11. Kong, B.Y., Haugh, I.M., Schlosser, B.J., Getsios, S. & Paller, A.S. J. Invest. Dermatol. 136, 12–14 (2016).

    Article  CAS  Google Scholar 

  12. Clayton, J.A. & Collins, F.S. Nature 509, 282–283 (2014).

    Article  Google Scholar 

Download references

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Correspondence to Timothy R D J Radstake.

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Pandit, A., Meyaard, L. & Radstake, T. Is sex bias orchestrated in the skin?. Nat Immunol 18, 142–143 (2017). https://doi.org/10.1038/ni.3658

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