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Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation

Nature Immunology volume 18, pages8–10(2017)Cite this article

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Different cellular sources and signaling mechanisms mediate the effects of IL-6 on the generation of pathogenic TH17 helper T cells and the suppression of Foxp3+ regulatory T cells.

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Figure 1: IL-6 sources and signaling modes regulate TH17 cells and Foxp3+ Treg cells differentially.

Marina Corral Spence/Springer Nature

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Affiliations

  1. Francisco J. Quintana is with the Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA, and The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

    Francisco J Quintana

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  1. Francisco J Quintana
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Correspondence to Francisco J Quintana.

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The author declares no competing financial interests.

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Quintana, F. Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation. Nat Immunol 18, 8–10 (2017). https://doi.org/10.1038/ni.3637

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