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Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation

Different cellular sources and signaling mechanisms mediate the effects of IL-6 on the generation of pathogenic TH17 helper T cells and the suppression of Foxp3+ regulatory T cells.

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Figure 1: IL-6 sources and signaling modes regulate TH17 cells and Foxp3+ Treg cells differentially.

Marina Corral Spence/Springer Nature


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Correspondence to Francisco J Quintana.

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Quintana, F. Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation. Nat Immunol 18, 8–10 (2017).

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