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How lymphocytes add up

A surprising molecular mechanism underlying signal integration and programmed proliferation in adaptive immunity has been identified: the cell-cycle regulator Myc enables a lymphocyte to add up the strength of signals it receives and time its response accordingly.

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Figure 1: Myc expression quantitatively regulates the program of lymphocyte proliferation in response to multiple signals.

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Correspondence to Becca Asquith.

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Asquith, B., de Boer, R. How lymphocytes add up. Nat Immunol 18, 12–13 (2017). https://doi.org/10.1038/ni.3636

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