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Phagocyte mayHEME caused by severe hemolysis

Free heme released by hemolysis directly inhibits bacterial phagocytosis by macrophages via alterations of actin cytoskeletal dynamics.

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Figure 1: Excess free heme perturbs the cytoskeletal dynamics of phagocytes, which results in the inhibition of phagocytosis and migration.

Kim Caesar/Nature Publishing Group


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Correspondence to Wolfgang Weninger.

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The authors declare no competing financial interests.

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Tan, SY., Weninger, W. Phagocyte mayHEME caused by severe hemolysis. Nat Immunol 17, 1335–1337 (2016).

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