Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

How MAIT cells get their start

By taking advantage of an MR1 tetramer to accurately detect mucosal-associated invariant T (MAIT) cells in both mice and humans, researchers defined the thymic development of MAIT cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Parallels and differences in development between MAIT cells and iNKT cells.

Kim Caesar/Nature Publishing Group

References

  1. Kjer-Nielsen, L. et al. Nature 491, 717–723 (2012).

    Article  CAS  Google Scholar 

  2. Franciszkiewicz, K. et al. Immunol. Rev. 272, 120–138 (2016).

    Article  CAS  Google Scholar 

  3. Reantragoon, R. et al. J. Exp. Med. 210, 2305–2320 (2013).

    Article  CAS  Google Scholar 

  4. Koay, H.-F. et al. Nat. Immunol. 17, 1300–1311 (2016).

    Article  CAS  Google Scholar 

  5. Seach, N. et al. J. Immunol. 191, 6002–6009 (2013).

    Article  CAS  Google Scholar 

  6. Lee, Y.J., Holzapfel, K.L., Zhu, J., Jameson, S.C. & Hogquist, K.A. Nat. Immunol. 14, 1146–1154 (2013).

    Article  CAS  Google Scholar 

  7. Engel, I. & Kronenberg, M. Curr. Top. Microbiol. Immunol. 381, 51–81 (2014).

    PubMed  Google Scholar 

  8. Pobezinsky, L.A. et al. Nat. Immunol. 16, 517–524 (2015).

    Article  CAS  Google Scholar 

  9. Le Bourhis, L. et al. Nat. Immunol. 11, 701–708 (2010).

    Article  CAS  Google Scholar 

  10. Martin, E. et al. PLoS Biol. 7, e54 (2009).

    Article  Google Scholar 

  11. Olszak, T. et al. Nature 509, 497–502 (2014).

    Article  CAS  Google Scholar 

  12. Chen, Z. et al. Mucosal Immunol. http://dx.doi.org/10.1038/mi.2016.39 (2016).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kristin A Hogquist.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, H., Hogquist, K. How MAIT cells get their start. Nat Immunol 17, 1238–1240 (2016). https://doi.org/10.1038/ni.3584

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3584

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing