Cracking the code of skin inflammation with CD1a

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CD1a on Langerhans cells in the epidermis is the lipid receptor for the plant-derived allergen urushiol and self lipids and is a key amplifier of inflammatory responses in urushiol-induced contact dermatitis as well as in psoriasis.

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Figure 1: CD1a presents lipid antigens and mediates urushiol-induced contact dermatitis and psoriasis.

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Correspondence to Masayuki Amagai.

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The author declares no competing financial interests.

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Amagai, M. Cracking the code of skin inflammation with CD1a. Nat Immunol 17, 1133–1134 (2016) doi:10.1038/ni.3557

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